Demoness's Art of Vengeance - Chapter 5: Nineform Spirituo-Demonic Refinement Technique

She was a medical genius from the Noah Medical Academy as well as a drug producing specialist. After sleeping for three days, she had returned to the ancient era and become the loyal marquis palace’s ignorant and silly young miss.

A wonder falling down from heaven! A boy possessed by strange blood! Gods tremble! Demons flee! A boy from the land of Dong Zhou. A pink skull as his sworn friend until death. A story of a determined warrior struggling for power. A legend that shakes the galaxy and disturbs the worlds of god, demon and man.

- Description from Novelupdates

Lin Dong came to the city from the mountains after cultivating medicine and martial arts to extremely high calibre. Wielding heavenly medicine skills and invincible martial arts, he dominates the city.

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Meet Sora and Shiro, a brother and sister who are loser shut-ins by normal standards. But these siblings don’t play by the rules of the “crappy game” that is average society. In the world of gaming, this genius pair reigns supreme, their invincible avatar so famous that it’s the stuff of urban legend. So when a young boy calling himself God summons the siblings to a fantastic alternate world where war is forbidden and all conflicts–even those involving national borders–are decided by the outcome of games, Sora and Shiro have pretty much hit the jackpot. But they soon learn that in this world, humanity, cornered and outnumbered by other species, survives within the confines of one city. Will Sora and Shiro, two failures at life, turn out to be the saviors of mankind? Let the games begin…