Immortality begins with Becoming an Alchemy Grandmaster - Chapter 290 - 149 Blood Talisman Appears in the

Xueyue's life was filled with nothing but unfortunate events. Her mother died giving birth to her, her father abandoned her for another family, her stepsister stole her beloved, and she was framed for a murder she didn't commit.
Sentenced to death by beating, Xueyue thought her horrible life would finally end.

Calling the old god’s mage, the knight who inherits the bloodline, looking forward to the glory of yesterday;

The noise of steam engines and the roar of cannons indicate the direction of the future;

An Sen, who was living in this world, embarked on a road that had never been imagined;

In the ashes of the old world…he shall be crowned king!

- Description from novelbuddy

In the year 298 from the era of the gods, elementary school girls Sumi Washio, Sonoko Nogi, and Gin Minowa are tasked with an important mission. They are to become heroes and fight Vertex, a mysterious enemy that is attacking Shinju-sama, the god tree that protects Shikoku, the only area in the world that is still habitable. What they don’t know, is that this fight will cost them more than they could have ever imagined.