MTL - Comprehensive Manga: The Wandering Ninja World Started From Questioning Payne - v2 Chapter 36 : Reproduce! Kaguya and Shirahoshi Appear!

Perhaps it is the choice of fate. As a senior otaku, Qian Lingfeng got the “steel shell system”. However, when he swept the world with the system, became a local rich man, made all kinds of beautiful women, opened a harem, and realized the ultimate fantasy of thousands of otaku, he found that things seemed far from simple!
When the end comes, biochemical zombies suddenly come down, fierce beasts are in power, bloodthirsty zerg roam to kill the world, and human lives are comparable to dirt. Where will weak human beings go in this world? Is humanity going to be extinct? Or … can an otaku save the fate of the human race?

- Description from Novelupdates

Chu Qiao was known as Agent 005 within the Secret Service’s 11th Division in her former life. She was locked up in the Secret Service’s prison as she was framed. After she successfully broke out from prison, she sacrificed her life bravely to preserve the Secret Service by defusing a bomb meant to wipe them out.

As a top cultivator in the Canglang Realm, Fang Mu has been a little troubled recently.

Because his new apprentice seems to be a little brainless.

…

Brain-disabled apprentice: “Master, the GM you killed is dead!”

Fang Mu: “Nonsense, people are killed and still not dead?”

Brain-disabled apprentice: “No, I mean, he died in the real world!”

Fang Mu: “Isn’t this the reality?”

The brain-dead apprentice “Of course not, you are just an NPC in the game!!!”

Fang Mu: “…”

…

Brain-disabled apprentice: “By the way, master, the last time it was a closed beta test, how come you haven’t been recalled?”

Fang Mu: “Oh, there was indeed a time travel back in the first two months.

But here I was blocked. ”

Brain-disabled apprentice: “Master, you are a bug…”

“Um?”

“Master, you will be corrected by GM with code!”

- Description from novelbuddy

For the wine to be drunk on her wedding night to actually have been a cup of poison and for the one to poison her to be her husband, who would believe it?