Naruto: The Hidden Protector - Chapter 2: Izanami Otsutsuki, the daughter of Hagoromo Ōtsutsuki.

A Pill Emperor of his generation was set up by a traitor.

Since then, the world lost a Qingyun Zi and gained an invincible silkpants.

Once again, walking the Great Dao of Alchemy.

How can I defy the heavens . . . with the medicine in my hands!

- Description from Novelupdates

At 3 years of age, her father went missing. At 15, the muscle in her hand snapped. At 16, her mother passed away in a car accident. At 19, she was framed by her uncle. At 22, she was burned alive by her newly- wedded husband and her best friend. Perhaps it was God’s sympathy that allowed her to return to the time when she was 15 years old to re-live once more. The previous lifetime of being low- key and having forbearance resulted in betrayal and misery. In this lifetime, she must be lofty and domineering to let those who have bullied her suffer a terrible end!

- Description from Novelupdates

Those people killed her grandmother, murdered her younger brother, trampled the people she deeply cared about, and even took her own life.

It was because she trusted her ambitious stepmother and half-sister;

because she mistakenly believed that womanly virtue is to have no talent;

because of her noble status and origin….This is what caused her death.

Buried in river water, Ouyang Nuan, gritted her teeth and spoke, “I, Ouyang Nuan was wronged in death. Even if it takes forever, I will become a devil, and in the next life, will not let you off!”

When she once again opened her eyes, Ouyang Nuan was sent back in time to when she was twelve years old. Around this age, her forehead was scarred, her brother fell into the water, and in three years she will be married…

In this life, she will try to change everything to guard and protect those she cares for from those with treacherous intentions. She will live a glorious life!

- Description from Novelupdates

Thanks to the so—called God, I somehow ended up as Uchiha Itachi’s younger brother and Sasuke’s twin.Wild, right?If I had to sum it up, I’d say, “Losing Shonen Jump is one thing, but losing your integrity? Now that’s a tragedy.”But let’s be real—none of that matters when you’ve got the Gojo System from the get-go. Yeah, you heard that right. From the moment I landed in this world, I was set to flex on the entire ninja world.And just like that, Konoha got itself a brand-new, utterly bizarre Uchiha.