MTL - The Science Fiction World of Xueba-Chapter 398 Non-coding RNA

Next, Pang Xuelin asked Jill to help arrange Ashford's place of residence. There were still empty rooms in the manor, just for Ashford to move in.

In the evening, Pang Xuelin hosted a banquet to clean up Ashford.

The Kempten base has ample food supplies, and even steaks, fish steaks, and red wine appeared at the banquet prepared by Jill.

After dinner, Pang Xuelin waved everyone, then pushed Ashford to the yard.

"Professor Pang, I think we need to talk frankly."

Ashford looked up at Pang Xuelin and took the lead.

"Okay, Mr. Ashford, what can you say directly?"

Pang Xuelin nodded and smiled.

The reason why he named Ashford from Spencer, on the one hand, Ashford's father, Ashford, originally founded the umbrella company with Spencer and Muskow, Ashford. You must know many secrets of the umbrella company.

On the other hand, as a top scholar who has been in the T virus field for more than ten years, Pang Xuelin believes that Ashford's understanding of the T virus is deeper than anyone at the Kempten base.

In the future, if he wants to find a way to deal with Spencer and others, I'm afraid he must start with Ashford.

"Professor Pang, I'm afraid you don't like the umbrella company?"

Pang Xuelin froze slightly, deliberately surprised: "Mr. Ashford, where do you start, I am now working well with Mr. Spencer, and the construction of Kempten base is also Thanks to the support of the umbrella company, why can't I feel bad about the umbrella company? "

Ashford chuckled and said lightly, "Professor Pang, you don't have to be so alert. In fact, not only can I see that, but you and Spencer are also well aware. But now you are each other. You need each other. The development of the Kempten base requires the financial support of the umbrella company. Spencer hopes to find the ultimate evolution direction from you, so you will not tear your face in a short time. "

After a pause, Ashford continued: "Professor Pang, I need your help."

"Need my help?"

Pang Xuelin froze.

Ashford's eyes glowed with hatred, saying: "You should know that my father, Ashford, worked with Muskow and Spencer to find the ancestral virus from West Africa and founded Ambrella. In the beginning, their goal was to use the special effects of the progenitor virus to find the future evolution of humanity and help humans overcome terminal illnesses such as cancer and AIDS. "

"But with the deepening of the research on the progenitor virus, they found that this virus showed amazing potential in biochemical weapons. So in the company's future development direction, my father, Muskow, and Spencer appeared At that time, a large part of the research and development department of Ambrella was my father's people. The scientists who participated in this project adhered to my father's philosophy and hoped to contribute to the future of mankind through the research of the progenitor virus. "

"In the end, in order to realize their ambitions, they even controlled my father in the laboratory and injected him with a virus as an experiment. Later, they announced that my father had actively participated in human experiments, and the experiments failed. Caused my father's death. In order to appease the people belonging to my father's faction in the company, they pushed me out again and became the so-called umbrella company three giants, but in fact, I was just a puppet in their hands, the reason I was pushed out just to prevent turmoil in the company. It was ridiculous that I was stupid at the time, thinking that my father had really died because of his active participation in the experiment. "

"It wasn't until later that I suffered another car accident. Although I lost my legs in the car accident, I was surprised to learn that all this was a conspiracy planned by Spencer and Muskou, and I realized that I was deceived by these two people. Later, Spencer's ambition expanded, and he tried to use Mascus again. I got the news in advance, and deliberately disclosed the news to Mascu. This was Masku's death. The reason for the resurrection ten years later. Over the years, the Ashford family ’s influence in the company has been declining. Coupled with my daughter ’s relationship, these years, I have always held hatred in my heart. I originally thought Through the resurrection of Muskow, he suffered spoils with Spencer, but I did not expect the two to reconcile now. They have met and decided to cooperate on your blood and T virus to develop a new generation. More powerful viruses ... "

Pang Xuelin could not help but hesitated, wondering: "Muscu and Spencer reconciled, why?"

Pang Xuelin, Muskow, and Spencer have all seen these two, and they are not some characters willing to subordinate to others.

Moreover, Spencer used his own hand to destroy Elvin's base under Muskou. The two should be more hostile to the sea, how could they join hands?

Ashford shook his head and said, "I do n’t know the specific reason, but this is what I have seen with my own eyes. Although the Ashford family has not had much influence in the umbrella company these years, there are still some inside the umbrella company. Some people are loyal to the Ashford family. According to the information returned by my people, inside the umbrella company, the loyalists who are loyal to Muskow and the loyal to Spencer are re-cooperating ... "

Having said that, Ashford looked up, staring at Pang Xuelin without blinking, "Professor Pang, only you can help me now ..."

Pang Xuelin said blankly: "Dr. Ashford, is your daughter still in Spencer's hands? Now you persuade me to fight Spencer, don't you worry about your daughter's safety?"

Ashford's face showed a bitterness, saying: "Muscu and Spencer merged, and my strength inside the umbrella company was very limited. Nowadays, man is stabbing me as fish. Our father and daughter are just puppets in his hands. If I hadn't got some key data about the T virus in my hands, I'd be dead. I have no other choice but to get rid of Spencer's control if I get angry. "

Pang Xuelin didn't say anything, he just looked at Ashford quietly.

"Professor Pang, do you still believe me?"

Pang Xuelin didn't speak, and it took a while before she said lightly, "Dr. Ashford, if I help you, what can you bring me?"

Ashford's eyes lighted and he said, "Professor Pang, you came from the hive laboratory. You should know the terrible T virus, but if I say, I have the weakness of the T virus, do you believe it? "

"The weakness of the T virus?"

Pang Xuelin froze slightly.

Ashford nodded: "Spencer was generally talented in the technical field. After Spencer 'killed' Muskow, research on the T virus fell into a stagnation state until I demonstrated heredity in biology. My father's talent, so Spencer put the research work on the T virus into my hands. Although these years I have been developing a new generation of biochemical weapons in accordance with Spencer's requirements, such as tyrants, lickers from It's in my hand. But in the process of studying these weapons, I have been trying to find a way to crack the T virus, and it really gave me some clues ... "

"What clue?"

"Professor Pang, have you heard of non-coding RNA?"

Pang Xuelin nodded.

"Since the famous DNA double helix model proposed by Watson and Crick in the 1950s, and the central law of genetic information flow from DNA → RNA → protein has been determined, we have realized that The complex structure and function are determined by the DNA sequence that becomes a gene on the genome and the protein that it expresses. Therefore, a gene on the genome is also called a coding sequence, which can encode the amino acid sequence of a protein. "

"But with our further research, we found that the coding sequence (that is, the gene) on the genome actually only accounts for a small part of the genome. In the human genome, the coding sequence only accounts for 3%, and the remaining 100% Nine-sevenths of the DNA sequence cannot encode any polypeptide or protein. This part of the DNA is the so-called non-coding sequence. And with our research on many organisms, we found that lower organisms, such as viruses, Bacteria, etc., have only a few non-coding sequences in their bodies, and higher plants and animals contain a large number of non-coding sequences, which occupy most of the genome. "

"And the central law tells us that an important way for DNA in the genome to function is to produce RNA by transcription. In recent years, our research shows that most of the DNA in the genome can be transcribed into RNA. Therefore, non-coding RNA has The non-coding sequences in the genome are transcribed, and there is more and more evidence that these non-coding RNAs play a very important role in life activities. The two most prominent examples are RNA interference and miA Research."

"The study of RNA interference stems from the phenomenon of post-transcriptional gene silencing, which was first discovered in petunia and a few plants. This particular phenomenon is manifested in the genes and Its similar endogenous genes are all suppressed, and further experiments show that homologous transcription did occur, but it was quickly degraded. "

"Scientists have further studied the phenomenon of RNA interference and found that once dsRNA enters the cell, it will be cut into 21 to 23 nucleotides by a specific enzyme called Dicer. The DiaseIII family can specifically recognize double-stranded RNA members. It cuts double-stranded RNA introduced by foreign sources or by various methods such as transgenes and viral infections in an ATP-dependent manner. The siRNA fragments generated by the cleavage are then combined with some enzymes to become Induced silencing complex. The activated silencing complex is localized to the mRNA transcript that is homologous to the siRNA through base pairing, and the mRNA is cut at a certain distance from the 3 'end of the siRNA, which corresponds to the mRNA. Genes are silent. Numerous studies have shown that RNA interference is widespread in organisms ranging from fungi to plants, invertebrates to mammals, and even in some lower prokaryotes. "

"At the time, a scientist in the hive laboratory proposed the idea that the gene silencing phenomenon is likely to be a defense mechanism against transposons or RNA viruses during the evolution of organisms. It is a kind of defense mechanism used by organisms. Ancient antiviral strategies may even have appeared before plants and animals differentiated. "

Pang Xuelin had a thoughtful expression on his face, saying, "What do you mean by studying the phenomenon of gene silencing may help us find a way to fight RNA viruses?"

Ashford shook his head and said, "Gene silencing can only make humans immune to some RNA viruses, so that surviving humans can be protected from T virus and its homologous viruses in the future. We really want to eliminate T virus. We There is still a long way to go. "

Pang Xuelin laughed and said, "Did you just say that there is miA in addition to the phenomenon of RNA interference? Tell me about this RNA."

Ashford nodded and said, "In the 1980s, I took over the hive laboratory. In one study, one of my experimental groups used nematodes as a target to study certain genes against them. Developmental effects ~ www.novelbuddy.com ~ We have found a gene that significantly interferes with development. Usually nematodes go through four larval stages before they mature. Mutations in this gene can keep its development in the first stage. Then let We were surprised that this gene also does not encode any protein, but only encodes one miA. "

"And this miA has actually inhibited the T virus in nematodes to a certain extent."

"Later we discovered that this miA belongs to a large non-coding RNA family. Over the years, the umbrella company's laboratory has discovered thousands of non-coding RNA molecules that form an interaction network. They are involved in the regulation of life activities in cells. They correspond to the protein-protein interaction network, just like dark matter and bright matter in cosmology. Previously, in the life sciences world, we always thought that the functions of living things were realized by proteins. Therefore, we have conducted a lot of research centering on proteins, and found a lot of pathways and related networks about protein production, regulation and metabolism. With the large-scale discovery of non-coding RNA and its biological functions, it will help us to find To the network of interactions between non-coding RNAs and even proteins ... "

Ashford paused and said, "Even, I think the antidote for the T virus is hidden in the millions of non-coding RNAs, depending on whether we can find it out."

Pang Xuelin looked at Ashford quietly. After a long time, he reached out and smiled, "Dr. Ashford, happy cooperation."

Ashford froze slightly, with a smile on her face: "Professor Pang, happy cooperation!"