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MTL - Doctor Chen, Don’t Be a Coward!-Chapter 331 Scumbag! (Thanks to the lord Mobai of Wishing Thousand Cities)
Chapter 331 Scumbag! (Thanks to the lord Mobai of Wishing Thousand Cities)
Chen Nan's words are really domineering.
Directly fooled everyone on the scene!
"They...do not deserve?!"
soon!
The audience fell into a discussion.
Yuan Chaomin and others looked confused. They looked at Chen Nan, obviously unable to understand the confidence of Chen Nan's words.
**** it!
They were really panicking inside.
They came to the meeting, and indeed they learned a lot of professional knowledge and the concept of new drugs.
Yuan Chaomin, Lu Shouyue and others also naturally hope that Chen Nan's drug will get attention and publicity on this platform.
After all, this is the scene of the world's top tumor new drug launch.
But!
Chen Nan actually started to fire at NMPA directly here, saying that their next-generation sequencing is outdated, and they are not worthy of genetic testing at all.
These words instantly annoyed everyone.
Sure enough, soon!
More people began to question Chen Nan.
After all, in addition to experts in the field of tumors, there were also many pharmaceutical companies presenting new drug launches.
What they got was also the sequencing result from NMPA.
A targeted drug must be sequenced to prove that it has a targeting effect on cancer cells, and only then can it obtain the threshold standard for targeted drugs.
Otherwise, even the name "targeted drug" cannot be pressed.
After being rejected by NMPA sequencing company, Chen Nan directly aimed his firepower at the other party.
Even said that the other party was not worthy of sequencing.
How arrogant and domineering is this?
In an instant, more and more people in the audience began to criticize Chen Nan.
"This... Chen Nan is too arrogant!"
"Yes, NMPA sequencing company is the current international standard, what qualifications does he have to say that he is not worthy!"
"That's right! What qualifications does he have to deny NMPA's sequencing standards?"
"Huaxia hasn't even developed a targeted drug, and it's ridiculous to talk about qualifications!"
"Yeah, I thought this young man was good, but this tone is too loud!"
…
Suddenly, more and more people began to question and even criticize Chen Nan's words.
On a stage like this, it is necessary to use strength to speak and use evidence to discuss facts.
It's not whoever has a loud voice, whoever has a hard tone, and whoever is more likely to quarrel.
Seeing Chen Nan like this.
Geoffrey, who was originally disgusted and angry with Chen Nan, suddenly laughed.
He was a little worried about Chen Nan's new medicine.
NMPA directly denied the targeting effect of icariin.
Even here, Chen Nan directly started to retaliate against the other party.
This was so hot that Joffrey didn't even have to stand up himself.
it's good now!
Chen Nan can be said to be enemies on all sides.
Even how many tongues he has, can he stop so many experts present?
Tilson felt dandruff and tingling.
Damn it, isn't Chen Nan too courageous?
Yesterday, it was Geoffrey who directly attacked Gilead. Today, Gilead’s stock price continued to slump.
To know!
Some time ago, Gilead's stock price can be said to be a very rare and good thing.
Now it is good, many stockholders are beginning to hesitate.
The United States can be said to be a country where all people participate in stock trading, and many people's savings are in the stock market.
And Chen Nan’s question about Gilead yesterday was quickly published in relevant medical newspapers, causing the other company’s shares to slump in an instant.
And today!
Chen Nan directly targeted NMPA Precision Medicine Company.
This operation made Tilson's waist tremble a little.
but!
Most people showed strong dislike for Chen Nan's words!
Even Drizzt frowned a little at this time.
Although he doesn't like those profit-seeking pharmaceutical companies, it is undeniable that they have made contributions to the development of the pharmaceutical industry.
However, Chen Nan is directly angry at NMPA, which makes Drizzt a little unhappy.
Although the World Cancer New Drug Conference welcomes new pharmaceutical products from all over the world, as long as they pass the review and have recommendations from regions or countries, they are eligible to enter this conference.
However, it does not mean that you can talk nonsense.
soon!
Someone stood up.
This is Brooks, the vice president of the Tumor Association.
Brooks got up and looked at Chen Nan and said:
"Professor Chen, your speech yesterday was a speech with suggestions for the World Cancer Society."
"But, it doesn't mean you can talk nonsense!"
"The significance of NMPA's existence has proved the value of the other party. Over the years, the strict review of targeted drugs has become known to the industry."
“Food and drug administrations in many countries will accept and recognize each other’s standards by default.”
"I want to know, why do you judge the other party like this?!"
"Is it just because you have not been certified by the other company?"
"If so, you are not a qualified tumor researcher."
Brooks' words attracted the attention of many people, and everyone started talking in low voices.
Joffrey was overjoyed when he saw this scene.
It can be said that he doesn't have any good feelings for Chen Nan now.
I wish the other party would encounter difficulties from everyone.
Chen Nan heard the sound and said with a smile: "Sir, I am naturally not talking nonsense."
"NMPA is still using next-generation gene sequencing technology."
"And my drug, icariin, is a multi-molecular target drug."
"He failed the test, which is a very normal thing."
"Actually, starting from this point, it can just prove the shortcomings and loopholes of next-generation sequencing."
"Besides, it's also within my expectation that it can't pass the other party's test!"
"Akolading's truly great place lies here!
It is different from the drug synthesis of screening targets, and it is not a one-way gene target.
The defect of next-generation sequencing is obvious, it is impossible to accurately predict gene fragments, and it is easy to cause errors!
If it is a targeted drug for the screening target, it can be verified through screening.
but!
Acladine is a multi-target small molecule therapeutic drug!
This means that the detection is very difficult and not specific, and it is easy to be negated by the second generation sequencing! "
Following Chen Nan's words, the audience fell silent instantly.
Because more and more people seem to realize that Chen Nan is not aimless.
It's not just a nonsense sophistry.
The other party really has something to say.
Currently the main targeted drugs for anticancer drugs are screening target types.
Next-generation sequencing can detect it and it seems to be normal.
Chen Nan saw that everyone in the audience was clearly attracted by his remarks.
I was overjoyed.
he knows!
The opportunity has come.
Chen Nan slid the device in his hand directly, and a detailed flow chart appeared on the big screen!
"Everyone can take a look!"
"This is the specific extreme of the drug Alcoradine."
"The core mechanism is down-regulation of inflammatory pathways!
That is, through the inhibition of IL-6/JAK2/STAT3 and TLR-MyD88-IKK-NFκB pathways, down-regulate the expression of TNF-α, IL-6, PD-L1, etc. to exert anti-tumor effects.
At the same time, through the regulation of MDSC\Tregs cells of immunosuppressive cells, the immune microenvironment can be adjusted and tumor growth can be inhibited. "
"This is a path very close to the activity of human immune cells!"
"Human immune cells are also a multi-target operation mechanism!"
"The same is true for our Acradine, it doesn't just act on tumor cells in the form of a drug!"
"It is through the regulation of immune cells to achieve the regulation of the immune microenvironment, so as to keep the development of cancer cells!"
“If we really want to say which drug our drug is more similar to, it must be CAR-T cell therapy.”
"but!"
"We are different from the other party in transforming T cells so that they do not meet the requirements of the human body."
"Instead, drugs are used to enhance the regulation of immune cells, so that the human body can become immune to cancer cells!"
The audience are all experts in the field of tumors in the world!
Those who can be invited to the meeting are by no means ordinary people.
On the stage, Chen Nan didn't have any timidity in his eyes, he was full of vigor, as if berating Fang Qiu.
Turn a blind eye to hundreds of experts and scholars in the audience, as well as journalists and media from pharmaceutical companies and professional journals around the world!
Those eyes are full of confidence.
Soon, Chen Nan's words attracted the attention of many people.
They began to think carefully along Chen Nan's thinking.
At this time, everyone did not continue to blame each other.
Joffrey panicked when he saw this.
He faintly felt something was wrong.
Brooks, too.
Accompanied by the approach of time one minute and one second.
Chen Nan's narration has attracted more and more people.
As Chen Nanyue said, the people below became more and more aware that something was wrong with this matter!
Because... Chen Nan began to gradually lead everyone to think in a new direction!
That's the question of gene sequencing!
That's right!
James Harken quickly realized this.
He even looked at Chen Nan in surprise, he faintly felt that something was wrong...
What is Chen Nan going to do?
Drizzt beside him was even more frowning!
He seemed to think of something.
Suddenly!
He opened his eyes suddenly, and looked at Chen Nan on the stage with sharp eyes.
He finally knew what Chen Nan was going to say!
Sequencing!
Chen Nan is not just releasing new drugs today.
It is undeniable that this drug called "Alcoradine" is indeed very attractive.
is also a novel idea!
but…
This is obviously not the reason that shocked him the most.
Chen Nan didn't seem to care too much about this drug.
Instead, it is taking this drug as an example to guide everyone's thinking and carry out a conceptual transformation!
In normal times, Drizzt would definitely stop it.
but!
At this time, Drizzt did not!
Because he thought of a special possibility.
That is... Where is the result of Chen Nan's guidance?
He took a deep breath, a little excited.
Could it be... Is Chen Nan really in the next generation of sequencing technology?
That's right!
Akoladine, under next-generation sequencing, cannot be completely denied. On the contrary, this multi-target drug is easier to identify.
but!
Under the current environment of screening targets, it is impossible for NMPA to pass Chen Nan!
Because once passed, there will be many problems!
First, the emergence of multi-target drugs will expose the defects of NMPA!
Second, next-generation sequencing technology is a phased product!
as expected!
With the passage of time every minute and every second.
Everyone in the audience is the top task in the field of tumors.
Whether it is the representatives of those pharmaceutical companies, the experts of the cancer associations present, or the leaders of academic journals.
They all vaguely grasped a little bit of something.
That is next-generation sequencing...seems to be falling behind the current tumor environment.
Targeted drugs are making progress!
This is undeniable.
With the continuous innovation of tumor-targeted drugs, drug resistance is constantly increasing. If sequencing technology cannot keep up, this will lead to a big disadvantage.
That is the curative effect!
Targeted drugs have always represented the pioneers of tumor drugs in the world.
But in fact, this is also a huge network of weaving.
When the sun rises, all deceptions will be self-defeating.
Oncology pharmaceutical companies have obviously reached an agreement with NMPA testing companies long ago.
That is to maintain the technical difficulty and mystery of targeted drugs.
But!
As the efficacy of the second-generation targeted drugs has become worse and worse, the third-generation targeted drugs have gradually entered the market, which has reached the peak and limit of the second-generation sequencing technology.
If you go one step further.
They simply can't meet the sequencing requirements.
The error rate will be greatly improved.
The difficulty of the fourth-generation targeted drugs is also increasing.
to be honest.
Targeted drugs, sooner or later, will step into the footsteps of antibiotics.
Accompanied by the enhanced drug resistance of cancer cells and changes in nucleic acid genes, this will lead to the dilemma of targeted drugs.
Precision medicine has already encountered a big problem...
so!
Accompanied by Chen Nan's speech, more and more people realized...Chen Nan might talk about "three generations of sequencing"? !
Thinking of this name, almost everyone's body trembled uncontrollably.
If so!
This…
This is too exciting.
Once the third-generation sequencing technology emerges, oncology drugs are bound to usher in a new opportunity for development. Similarly, this will also allow oncology pharmaceutical companies to undergo a new reshuffle.
One time!
More and more people can't help wrapping their clothes tightly.
Although the temperature on the south coast of the United States is not cold.
However, even so, everyone in the Rochester Hotel still felt a kind of excitement before the climax!
Yuan Chaomin and others are even more so.
Before, they were full of curiosity about Chen Nan.
Even... Everyone was a little confused about what Chen Nan was going to do.
but!
Accompanied by Chen Nan's analysis of the drug Acradine, and with Chen Nan bringing out some special information from the third-generation sequencing, it seems... a mysterious picture scroll is unfolding!
Lv Shouyue and others looked at Chen Nan on the stage, and suddenly felt strange.
Is this Xiao Chen?
Is this really Xiao Chen who came here with them from China for a new drug launch conference, the first time to participate in such a high-end international conference?
This…
Looking at the audience, how many people looked at Chen Nan with burning eyes.
That's right!
Tilson was excited all over.
He's waiting!
Wait for Chen Nan to say the words three-generation sequencing.
James Harken is waiting!
Dane is waiting too!
And Drizzt is also waiting.
In the room, hundreds of people almost stood up, waiting for Chen Nan to say the words "three generations of sequencing"!
pity!
Just at this time.
Chen Nan looked up at the time, and suddenly bowed to everyone!
smiled and said:
"thanks!"
"This concludes my report for today."
"Akladine will definitely become a targeted drug with cross-age significance!"
"because…"
"Secret!"
After finishing speaking, Chen Nan walked straight down the stage.
And this scene!
Suddenly everyone in the audience was dumbfounded.
This?
this one?
Is this the end?
Does it fit?
That's right!
Everyone was dumbfounded.
We're all posing, our interest is maxed out...
You went down?
I'm all undressed, you show me this?
That's how it feels!
Chen Nan came back suddenly and added:
"Today is the press conference for new tumor drugs."
"We only talk about new drugs, nothing else!"
"thanks for your support!"
After finishing speaking, Chen Nan walked towards the audience.
And hundreds of pairs of eyes stared at him.
Although Chen Nan didn't say a single word of "Three Generation Sequencing".
but!
No one doubts whether Chen Nan understands the third-generation sequencing technology!
even!
Many people began to think about it.
Could it be...
Three-generation sequencing, has it come out?
One time!
The souls of all the people were hooked away by Chen Nan unconsciously.
As a result, the next new drug launch conference seemed a little less exciting.
Jewels come first.
Everyone feels that after drinking a good wine, that taste is taken away, and then...the taste after that is always worse.
Those pharmaceutical companies are also dumbfounded.
Damn it!
Originally wanted to rely on this new drug to show it on such a stage.
But…
Everyone is not even interested in asking questions.
We've been preparing for this for a long time, okay?
Can you ask me a question?
Even one question is fine!
pity!
Everyone's thoughts are on Chen Nan.
He was like a scumbag, seduced the thoughts of all the beautiful girls, and then patted his **** and left?
Really is…
Scumbag!
Phew!
…
…
The meeting is over soon.
This will mean that this time the new drug launch conference has come to a successful conclusion.
Drizzt came to the stage and made a summary.
There is a grand luncheon at noon.
This luncheon is of a business nature.
The experts who come to the meeting will have friendly talks with pharmaceutical companies here, and get the qualifications for donating medicines, participating in drug clinical trials, and recommending opportunities for free diagnosis and treatment.
In the past, Yuan Chaomin and others were generally lonely and lonely.
Compared to those lively other experts, they only obtained some qualifications symbolically.
but…
This time!
But it is completely different from before.
The Huaxia expert group actually obtained an independent banquet restaurant.
The restaurant is as luxurious as a meeting place.
Before the luncheon started, a group of people could not wait to walk in.
, Chen Nan and others left their contact information one after another.
"Professor Chen, it's a pleasure to meet you. I'm the vice president of Pfizer Pharmaceuticals. I think we will have many cooperation projects!"
"We are very interested in your icariin."
"I think we can have a deeper understanding and communication."
…
"Professor Chen, hello, I am from Johnson & Johnson..."
"Professor Chen, it's a pleasure to meet you. We are Roche... I think that you meet the qualifications for our senior professor to donate medicines, and we will give you special rights to donate medicines..."
"..."
…
More and more big-name companies have come to seek further cooperation with Chen Nan.
These pharmaceutical companies are not stupid!
There is only one purpose for their humility.
That is three-generation sequencing.
Almost everyone has a premonition that Chen Nan definitely has information about the third-generation sequencing.
Otherwise, it would be impossible to make such a display at the scene of new drug release.
Chen Nan has obtained the authorization of advanced drug donation qualifications from almost all pharmaceutical companies at once.
In the United States, there are many clinical trials, and these trials are generally phase III clinical trials, with a high safety factor.
And, the key is free healthcare.
You must know that the price of these new drugs is very expensive, and the price is tens of thousands or hundreds of thousands. For many families, it is very difficult.
However, the quota for Phase III clinical trials is not easy to get.
Phase III clinical trials of common drugs still need to take the initiative to spend money to find people!
However, for those targeted drugs with high maturity and expensive drugs, a chance for a clinical trial is very rare!
But Chen Nan has a lot in his hand!
These pharmaceutical companies are not stupid.
They just want to get the latest third-generation sequencing information from Chen Nan.
For these large international pharmaceutical companies, the first opportunity represents the future market share!
However, Chen Nan pretended to be confused and pretended not to understand.
And when the representatives of the pharmaceutical company left.
Yuan Chaomin just had time to eat, he looked at the splendid and magnificent private room, and said with some emotion: "Unbelievable..."
"It's all... true!"
"How can we be so popular?"
Lu Shouyue smiled wryly: "That's the truth."
Yang Fupeng on the side was the most successful one.
When he learned that Yang Fupeng was brought by Chen Nan, he was not eligible to donate medicine.
But he got the qualification second only to Chen Nan!
After saying this, Yang Fupeng felt like he was dreaming.
**** it!
The feeling of hugging the thigh is really comfortable.
hug more in the future...
Yuan Chaomin suddenly lowered his voice at this time, and said to Chen Nan:
"Professor Chen, do you really...understand that?"
Chen Nan was taken aback: "What?"
Yuan Chaomin was tickled by Chen Nan: "That's it!"
"The one you said! Three generations!"
"Three generations!"
Chen Nan smiled: "Secret!"
Suddenly, Yuan Chaomin lost his anger and started to eat angrily.
The food is delicious!
He eats very quickly.
However, he soon discovered that eating fast is a good thing.
Because soon, an endless stream of experts came to talk to Chen Nan and left their contact information...
Chen Nan didn't refuse either.
However, when he saw those experts who would rather not attend the meeting for his sake, and those who helped him speak.
In the remarks column, there is a special symbol.
Wait until the luncheon is over.
Yuan Chaomin and others are going back to the hotel.
Chen Nan was personally invited by Drizzt to chat in the room.
Straight to the point, Drizzt directly took out an invitation letter!
"Professor Chen, I would like to invite you to join the World Cancer Society!"
"However, according to our rules, there is no way for you to be directly elected to the council."
"So, we can only give you a membership invitation letter."
"At the same time, won the title of Honorary Director in China."
"Our Tumor Association needs talents like you."
Chen Nan was stunned for a moment!
"Is this...appropriate?"
Drizzt smiled slightly: "We, the World Cancer Society, serve patients, and ability is the only criterion for testing!"
"And you, have such ability!"
Chen Nan smiled and did not refuse.
After the two chatted a lot, Drizzt still couldn't hold back his inner curiosity, and asked, "Director Chen, the third-generation sequencing...do you really have an idea?"
Chen Nan looked at Drizzt, nodded and smiled slightly.
then turned and left!
Leaving Drizzt standing in the room, he didn't turn around for a long time!
really have? !
real!
Drizzt was very excited.
…
…
End of the meeting,
The last day is still a pharmaceutical company entertainment event.
As for Shen Guzhang, here he saw his son after the operation.
He looked at Shen Yuzhe who was lying on the bed, staring blankly out of the window, feeling extremely distressed!
This blow was too serious for Shen Yuzhe.
The operation was a success!
Eighty percent of Shen Yuzhe's tongue was cut off.
Although tongue reconstruction surgery was performed, but...a prosthesis is a prosthesis after all.
Henceforth!
The delicacy of the world has nothing to do with him.
The ups and downs, from now on farewell.
Even talking...
have become very difficult.
all of these!
For Shen Yuzhe, it was a big blow.
Shen Guzhang was about to speak when he suddenly saw a newspaper in Shen Yuzhe's hand!
"The Rochester Special"
This is a very famous local media.
And key!
On the cover, there is a young man, imposing, with sharp eyes and full of confidence!
And the title is like this!
《The mysterious TCM genius from the East, a blockbuster at the World Cancer Drug Conference! "
Such a headline, in China, is absolutely impossible for even the UC editorial department to report it.
But!
In the United States, it has attracted a lot of attention.
Chen Nan's demeanor at this meeting was immediately known to many people in the United States.
When Shen Guzhang saw this scene, he was extremely angry in his heart!
He quickly picked up the newspaper and was about to throw it away.
was suddenly grabbed by Shen Yuzhe.
"Son, don't worry!"
"There is a dad!"
"don’t worry!"
"I remember this hatred..."
Shen Yuzhe's eyes were empty, as if he had lost his soul.
And he turned around slowly, looked at Shen Guzhang, tears streaming down his face.
He has too many grievances and wants to vent.
Originally thought that coming to the United States this time would be a good way to embarrass Chen Nan.
But, who would have thought?
Chen Nana did not attend the meeting, and at the meeting site, let Geoffrey lose to Maicheng, the stock price was low, and faced with NMPA's doubts, he was even more angry with the other party, causing the other party to fall into a stalemate.
The key point is that the new drug he came up with, Akladine, became a blockbuster.
Even brought out some information from the third-generation sequencing, which attracted everyone.
If you say, who is the most dazzling person in this year's new drug conference, it would be Chen Nan!
the next day!
Award ceremony!
Sure enough, not everyone expected.
Chen Nan won this year's most anticipated new drug award.
This title is equivalent to this year's best performance award.
However, no one doubted or questioned Chen Nan's award.
Now, many people are guessing, Chen Nan really mastered the third-generation sequencing technology?
Not only them!
Even in China at this time.
Qin Shiming and others urgently held a meeting to discuss the third-generation sequencing technology.
Because it started yesterday!
Qin Shiming received no less than fifty calls one after another.
All come from major pharmaceutical companies, as well as some cooperative countries and friendly academic exchange countries.
Their problem, only one!
That is the problem of three-generation sequencing.
This question stunned Qin Shiming.
Even a little confused what is going on?
Until later!
He knew the truth.
Qin Shiming was also a little confused.
Chen Nan really mastered the third-generation sequencing technology?
What if this is true?
This is amazing!
Qin Shiming thought of this, and quickly called Chen Nan!
asked straight to the point:
"Xiao Chen, do you understand three-generation sequencing?"
Chen Nan responded tactfully: "Well, understand a little bit!"
Qin Shiming, who heard Chen Nan's reply with his own ears, suddenly became excited.
"it is good!"
"OK!"
"This is a big deal!"
But what Chen Nan said next made Qin Shiming stunned.
"But... Mr. Qin, this technology is not mine."
"It's one of my partners."
"The other party is a research institute opened in the United States. For the third-generation sequencing, the research was relatively early, and now it has achieved results."
"But... I don't have enough voice."
Chen Nan's words made Qin Shiming stunned and even a little disappointed.
actually!
There is a reason why Chen Nan said that.
The new drug Acradine some time ago can attract the attention of those crazy bees and butterflies.
Even unscrupulous start!
He didn't even dare to imagine, if this technology is used, will there be a stronger force to make a move?
Chen Nan is patriotic!
I also want to contribute to the country.
However, he wants to ensure his own safety first, and he hopes that he can have chips in his hand.
Moreover, as a genetic testing company, he can discuss cooperation with the country openly.
Hua Ran, if the operation is better.
It will even become a trump card in Chen Nan's hand!
That's why he made these remarks.
"Can you get in touch with him?"
Chen Nan nodded: "Yes!"
After Qin Shiming finished listening, he became excited.
"it is good!"
"Row!"
"By the way, Xiao Chen, congratulations on winning the honor of the most anticipated new drug."
"Come back, I'll give you a celebration banquet!"
Chen Nan smiled and nodded: "Thank you, Director."
…
the next day.
Chen Nan was about to return home, but received a special invitation.
The inviter is Dane's teacher.
Chief oncologist at the Mayo Clinic in Rochester.
Mr. Nelson!
This person is also the vice president of the World Cancer Society.
Chen Nan looked at the time, he was on an evening flight in the afternoon, so he was not in a hurry.
The other party's invitation is to hope that Chen Nan can help diagnose and treat a patient.
Dane personally invited Chen Nan.
Regarding this, Chen Nan did not refuse,
"Okay, just pick me up tomorrow."
Dane smiled gratefully when he heard the sound: "Thank you, Professor Chen."
"Also, congratulations on joining the World Cancer Society."
Chen Nan couldn't help smiling, and smiled.
"What's the congratulations."
"Professor Dane is already a member of the association."
Dane shook his head: "No, there is a big difference."
"The Tumor Association, invited by the president, has a high gold content."
Chen Nan asked curiously at this time: "By the way, who is the patient?"
Dane suddenly said: "Chinese American."
"The old gentleman is very old."
"Professor Nelson wants your help."
Chen Nan became even more curious.
…
ps: Thanks to the leader of "Wishing Thousands of Cities Mobai" for his heroic reward of 100,000, becoming the 20th leader of this book, sincere thanks!
(end of this chapter)